Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds
نویسندگان
چکیده
منابع مشابه
Modulation of internuclear communication in multinuclear Ruthenium(II) polypyridyl complexes
The synthesis and characterization of dinuclear ruthenium polypyridyl complexes based on the bridging ligands 1,3-bis-(5’-(pyridin-2’’-yl)-1’H-1’,2’,4’-triaz-3’-yl)-benzene, 1,4-bis-(5’-(pyridin-2’’-yl)-1’H-1’,2’,4’-triaz-3’-yl)-benzene, 2,5-bis-(5’-(pyridin-2’’yl)-1’H-1’,2’,4’-triaz-3’-yl)-thiophene, 2,5-bis-(5’-(pyrazin-2’’-yl)-1’H-1’,2’,4’-triaz3’-yl)-thiophene, and of their mononuclear anal...
متن کاملInfluence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohex...
متن کاملArene ruthenium complexes as anticancer agents.
Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as hydrophobic properties due to the robustness of the ruthenium-arene unit hold a high potential for the development of metal-based anticancer drugs. Mononuclear arene ruthenium complexes containing P- or N-donor ligands or N,N-, N,O- or O,O-chelating ligands, dinuclear arene ruthenium systems with adjustable orga...
متن کاملAnticancer activity of opened arene ruthenium metalla-assemblies.
Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. ...
متن کاملSynthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles
Arene ruthenium complexes containing long-chain N-ligands L = NC5H4–4-COO–C6H4–4-O–(CH2)9–CH3 or L 2 = NC5H4–4-COO–(CH2)10– O–C6H4–4-COO–C6H4–4-C6H4–4-CN derived from isonicotinic acid, of the type [(arene)Ru(L)Cl2] (arene = C6H6, L = L : 1; arene = p-MeC6H4Pr , L = L: 2; arene = C6Me6, L = L : 3; arene = C6H6, L = L : 4; arene = p-MeC6H4Pr , L = L: 5; arene = C6Me6, L = L : 6) have been synthe...
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ژورنال
عنوان ژورنال: Journal of Organometallic Chemistry
سال: 2009
ISSN: 0022-328X
DOI: 10.1016/j.jorganchem.2009.06.028